Histone deacetylase inhibitors as radiosensitisers: effects on DNA damage signalling and repair

Many cancers display increased expression of histone deacetylases (HDACs) and therefore transcriptionally inactive chromatin, resulting in the downregulation of genes including tumour suppressor and DNA repair genes. Histone deacetylase inhibitors (HDACi) are a heterogeneous group of epigenetic ther...

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Detalles Bibliográficos
Autores principales: Groselj, B, Sharma, N L, Hamdy, F C, Kerr, M, Kiltie, A E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Minireview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3590661/
https://www.ncbi.nlm.nih.gov/pubmed/23361058
http://dx.doi.org/10.1038/bjc.2013.21

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3590661/
https://www.ncbi.nlm.nih.gov/pubmed/23361058
http://dx.doi.org/10.1038/bjc.2013.21

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