Cytosine-based nucleoside analogs are selectively lethal to DNA mismatch repair-deficient tumour cells by enhancing levels of intracellular oxidative stress

BACKGROUND: DNA mismatch repair deficiency is present in a significant proportion of a number of solid tumours and is associated with distinct clinical behaviour. METHODS: To identify the therapeutic agents that might show selectivity for mismatch repair-deficient tumour cells, we screened a pair of...

Descripción completa

Detalles Bibliográficos
Autores principales: Hewish, M, Martin, S A, Elliott, R, Cunningham, D, Lord, C J, Ashworth, A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3590674/
https://www.ncbi.nlm.nih.gov/pubmed/23361057
http://dx.doi.org/10.1038/bjc.2013.3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3590674/
https://www.ncbi.nlm.nih.gov/pubmed/23361057
http://dx.doi.org/10.1038/bjc.2013.3

Ejemplares similares