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Cytosine-based nucleoside analogs are selectively lethal to DNA mismatch repair-deficient tumour cells by enhancing levels of intracellular oxidative stress

BACKGROUND: DNA mismatch repair deficiency is present in a significant proportion of a number of solid tumours and is associated with distinct clinical behaviour. METHODS: To identify the therapeutic agents that might show selectivity for mismatch repair-deficient tumour cells, we screened a pair of...

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Detalles Bibliográficos
Autores principales:	Hewish, M, Martin, S A, Elliott, R, Cunningham, D, Lord, C J, Ashworth, A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2013
Materias:	Genetics and Genomics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3590674/ https://www.ncbi.nlm.nih.gov/pubmed/23361057 http://dx.doi.org/10.1038/bjc.2013.3

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