Structural basis for ion permeation mechanism in pentameric ligand-gated ion channels

To understand the molecular mechanism of ion permeation in pentameric ligand-gated ion channels (pLGIC), we solved the structure of an open form of GLIC, a prokaryotic pLGIC, at 2.4 Å. Anomalous diffraction data were used to place bound anions and cations. This reveals ordered water molecules at the...

Descripción completa

Detalles Bibliográficos
Autores principales: Sauguet, Ludovic, Poitevin, Frédéric, Murail, Samuel, Van Renterghem, Catherine, Moraga-Cid, Gustavo, Malherbe, Laurie, Thompson, Andrew W, Koehl, Patrice, Corringer, Pierre-Jean, Baaden, Marc, Delarue, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Molecular Biology Organization 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3590989/
https://www.ncbi.nlm.nih.gov/pubmed/23403925
http://dx.doi.org/10.1038/emboj.2013.17

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3590989/
https://www.ncbi.nlm.nih.gov/pubmed/23403925
http://dx.doi.org/10.1038/emboj.2013.17

Ejemplares similares