Neonatal levels of acute phase proteins and later risk of non-affective psychosis

Mounting evidence suggests that immune disturbances in early life may be implicated in the etiology of non-affective psychoses. Our aim was to assess the levels of neonatal acute phase proteins (APPs), central to innate immune function as well as central nervous system development, in neonatal dried...

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Autores principales: Gardner, R M, Dalman, C, Wicks, S, Lee, B K, Karlsson, H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3591005/
https://www.ncbi.nlm.nih.gov/pubmed/23423137
http://dx.doi.org/10.1038/tp.2013.5
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author Gardner, R M
Dalman, C
Wicks, S
Lee, B K
Karlsson, H
author_facet Gardner, R M
Dalman, C
Wicks, S
Lee, B K
Karlsson, H
author_sort Gardner, R M
collection PubMed
description Mounting evidence suggests that immune disturbances in early life may be implicated in the etiology of non-affective psychoses. Our aim was to assess the levels of neonatal acute phase proteins (APPs), central to innate immune function as well as central nervous system development, in neonatal dried blood spots and their association with later risk of non-affective psychoses. This case-control study included 196 individuals with a verified register-based diagnosis of non-affective psychosis and 502 controls matched on age, sex and hospital of birth. Concentrations of nine different APPs were measured in eluates from dried blood spots using a bead-based multiplex assay. Odds ratios (OR) for non-affective psychoses were calculated for log(2)-transformed (continuous) as well as tertiles of APP concentrations. In continuous analysis, higher concentrations of two APPs, tissue plasminogen activator (tPA; OR: 0.90, 95% confidence interval (CI): 0.85–0.96) and serum amyloid P (SAP; OR: 0.88, 95% CI: 0.78–0.99) were protective in terms of risk of non-affective psychosis. These relationships were not affected by the addition of covariates relevant to maternal health, pregnancy and delivery to the model. Tertile analysis confirmed a protective relationship for higher levels of tPA and SAP, as well as for procalcitonin (highest tertile OR: 0.54, 95% CI:0.32–0.91). Our results suggest that persons who develop non-affective psychoses have lower levels of certain APPs at the time of birth. These differences may render individuals more susceptible to infectious diseases or cause deficiencies in pathways critical for neurodevelopment.
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spelling pubmed-35910052013-03-12 Neonatal levels of acute phase proteins and later risk of non-affective psychosis Gardner, R M Dalman, C Wicks, S Lee, B K Karlsson, H Transl Psychiatry Original Article Mounting evidence suggests that immune disturbances in early life may be implicated in the etiology of non-affective psychoses. Our aim was to assess the levels of neonatal acute phase proteins (APPs), central to innate immune function as well as central nervous system development, in neonatal dried blood spots and their association with later risk of non-affective psychoses. This case-control study included 196 individuals with a verified register-based diagnosis of non-affective psychosis and 502 controls matched on age, sex and hospital of birth. Concentrations of nine different APPs were measured in eluates from dried blood spots using a bead-based multiplex assay. Odds ratios (OR) for non-affective psychoses were calculated for log(2)-transformed (continuous) as well as tertiles of APP concentrations. In continuous analysis, higher concentrations of two APPs, tissue plasminogen activator (tPA; OR: 0.90, 95% confidence interval (CI): 0.85–0.96) and serum amyloid P (SAP; OR: 0.88, 95% CI: 0.78–0.99) were protective in terms of risk of non-affective psychosis. These relationships were not affected by the addition of covariates relevant to maternal health, pregnancy and delivery to the model. Tertile analysis confirmed a protective relationship for higher levels of tPA and SAP, as well as for procalcitonin (highest tertile OR: 0.54, 95% CI:0.32–0.91). Our results suggest that persons who develop non-affective psychoses have lower levels of certain APPs at the time of birth. These differences may render individuals more susceptible to infectious diseases or cause deficiencies in pathways critical for neurodevelopment. Nature Publishing Group 2013-02 2013-02-19 /pmc/articles/PMC3591005/ /pubmed/23423137 http://dx.doi.org/10.1038/tp.2013.5 Text en Copyright © 2013 Macmillan Publishers Limited http://creativecommons.org/licenses/by-nc-sa/3.0/ This work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/
spellingShingle Original Article
Gardner, R M
Dalman, C
Wicks, S
Lee, B K
Karlsson, H
Neonatal levels of acute phase proteins and later risk of non-affective psychosis
title Neonatal levels of acute phase proteins and later risk of non-affective psychosis
title_full Neonatal levels of acute phase proteins and later risk of non-affective psychosis
title_fullStr Neonatal levels of acute phase proteins and later risk of non-affective psychosis
title_full_unstemmed Neonatal levels of acute phase proteins and later risk of non-affective psychosis
title_short Neonatal levels of acute phase proteins and later risk of non-affective psychosis
title_sort neonatal levels of acute phase proteins and later risk of non-affective psychosis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3591005/
https://www.ncbi.nlm.nih.gov/pubmed/23423137
http://dx.doi.org/10.1038/tp.2013.5
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