Oxidative Stress Induces Mitochondrial DNA Damage and Cytotoxicity through Independent Mechanisms in Human Cancer Cells

Intrinsic oxidative stress through increased production of reactive oxygen species (ROS) is associated with carcinogenic transformation, cell toxicity, and DNA damage. Mitochondrial DNA (mtDNA) is a natural surrogate to oxidative DNA damage. MtDNA damage results in the loss of its supercoiled struct...

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Detalles Bibliográficos
Autores principales: Han, Yue, Chen, Junjian Z.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3591153/
https://www.ncbi.nlm.nih.gov/pubmed/23509785
http://dx.doi.org/10.1155/2013/825065

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3591153/
https://www.ncbi.nlm.nih.gov/pubmed/23509785
http://dx.doi.org/10.1155/2013/825065

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