Chemical Modifications of PhTX-I Myotoxin from Porthidium hyoprora Snake Venom: Effects on Structural, Enzymatic, and Pharmacological Properties

We recently described the isolation of a basic PLA(2) (PhTX-I) from Porthidium hyoprora snake venom. This toxin exhibits high catalytic activity, induces in vivo myotoxicity, moderates footpad edema, and causes in vitro neuromuscular blockade. Here, we describe the chemical modifications of specific...

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Detalles Bibliográficos
Autores principales: Huancahuire-Vega, Salomón, Corrêa, Daniel H. A., Hollanda, Luciana M., Lancellotti, Marcelo, Ramos, Carlos H. I., Ponce-Soto, Luis Alberto, Marangoni, Sergio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3591178/
https://www.ncbi.nlm.nih.gov/pubmed/23484072
http://dx.doi.org/10.1155/2013/103494

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3591178/
https://www.ncbi.nlm.nih.gov/pubmed/23484072
http://dx.doi.org/10.1155/2013/103494

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