Harmine and Harmaline Downregulate TCDD-Induced Cyp1a1 in the Livers and Lungs of C57BL/6 Mice

We previously demonstrated that Peganum harmala L. extract and its main active constituents, harmine and harmaline inhibit the 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-mediated induction of the carcinogen-activating enzyme, Cyp1a1, in vitro. However, the effect of both alkaloids on Cyp1a1 in vivo...

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Detalles Bibliográficos
Autores principales: El Gendy, Mohamed A. M., El-Kadi, Ayman O. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3591235/
https://www.ncbi.nlm.nih.gov/pubmed/23509697
http://dx.doi.org/10.1155/2013/258095

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3591235/
https://www.ncbi.nlm.nih.gov/pubmed/23509697
http://dx.doi.org/10.1155/2013/258095

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