Dantrolene-Induced Inhibition of Skeletal L-Type Ca(2+) Current Requires RyR1 Expression

Malignant hyperthermia (MH) is a pharmacogenetic disorder most often linked to mutations in the type 1 ryanodine receptor (RyR1) or the skeletal L-type Ca(2+) channel (Ca(V)1.1). The only effective treatment for an MH crisis is administration of the hydantoin derivative Dantrolene. In addition to re...

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Detalles Bibliográficos
Autor principal: Bannister, R. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3591246/
https://www.ncbi.nlm.nih.gov/pubmed/23509717
http://dx.doi.org/10.1155/2013/390493

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3591246/
https://www.ncbi.nlm.nih.gov/pubmed/23509717
http://dx.doi.org/10.1155/2013/390493

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