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Dantrolene-Induced Inhibition of Skeletal L-Type Ca(2+) Current Requires RyR1 Expression
Malignant hyperthermia (MH) is a pharmacogenetic disorder most often linked to mutations in the type 1 ryanodine receptor (RyR1) or the skeletal L-type Ca(2+) channel (Ca(V)1.1). The only effective treatment for an MH crisis is administration of the hydantoin derivative Dantrolene. In addition to re...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Hindawi Publishing Corporation
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3591246/ https://www.ncbi.nlm.nih.gov/pubmed/23509717 http://dx.doi.org/10.1155/2013/390493 |