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Positively Selected Sites in Cetacean Myoglobins Contribute to Protein Stability

Since divergence ∼50 Ma ago from their terrestrial ancestors, cetaceans underwent a series of adaptations such as a ∼10–20 fold increase in myoglobin (Mb) concentration in skeletal muscle, critical for increasing oxygen storage capacity and prolonging dive time. Whereas the O(2)-binding affinity of...

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Detalles Bibliográficos
Autores principales: Dasmeh, Pouria, Serohijos, Adrian W. R., Kepp, Kasper P., Shakhnovich, Eugene I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3591298/
https://www.ncbi.nlm.nih.gov/pubmed/23505347
http://dx.doi.org/10.1371/journal.pcbi.1002929