Combined Delivery of Paclitaxel and Tanespimycin via Micellar Nanocarriers: Pharmacokinetics, Efficacy and Metabolomic Analysis

BACKGROUND: Despite the promising anticancer efficacy observed in preclinical studies, paclitaxel and tanespimycin (17-AAG) combination therapy has yielded meager responses in a phase I clinical trial. One serious problem associated with paclitaxel/17-AAG combination therapy is the employment of lar...

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Detalles Bibliográficos
Autores principales: Katragadda, Usha, Fan, Wei, Wang, Yingzhe, Teng, Quincy, Tan, Chalet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3591361/
https://www.ncbi.nlm.nih.gov/pubmed/23505544
http://dx.doi.org/10.1371/journal.pone.0058619

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3591361/
https://www.ncbi.nlm.nih.gov/pubmed/23505544
http://dx.doi.org/10.1371/journal.pone.0058619

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