Amitozyn Impairs Chromosome Segregation and Induces Apoptosis via Mitotic Checkpoint Activation

Amitozyn (Am) is a semi-synthetic drug produced by the alkylation of major celandine (Chelidonium majus L.) alkaloids with the organophosphorous compound N,N’N’-triethylenethiophosphoramide (ThioTEPA). We show here that the treatment of living cells with Am reversibly perturbs the microtubule cytosk...

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Detalles Bibliográficos
Autores principales: Herman, Bastien, Gudrun, Aldrian, Potopalsky, Anatoly I., Chroboczek, Jadwiga, Tcherniuk, Sergey O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3591406/
https://www.ncbi.nlm.nih.gov/pubmed/23505430
http://dx.doi.org/10.1371/journal.pone.0057461

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3591406/
https://www.ncbi.nlm.nih.gov/pubmed/23505430
http://dx.doi.org/10.1371/journal.pone.0057461

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