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Amitozyn Impairs Chromosome Segregation and Induces Apoptosis via Mitotic Checkpoint Activation
Amitozyn (Am) is a semi-synthetic drug produced by the alkylation of major celandine (Chelidonium majus L.) alkaloids with the organophosphorous compound N,N’N’-triethylenethiophosphoramide (ThioTEPA). We show here that the treatment of living cells with Am reversibly perturbs the microtubule cytosk...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3591406/ https://www.ncbi.nlm.nih.gov/pubmed/23505430 http://dx.doi.org/10.1371/journal.pone.0057461 |