Site-Specific Perturbations of Alpha-Synuclein Fibril Structure by the Parkinson's Disease Associated Mutations A53T and E46K

Parkinson's disease (PD) is pathologically characterized by the presence of Lewy bodies (LBs) in dopaminergic neurons of the substantia nigra. These intracellular inclusions are largely composed of misfolded α-synuclein (AS), a neuronal protein that is abundant in the vertebrate brain. Point mu...

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Detalles Bibliográficos
Autores principales: Lemkau, Luisel R., Comellas, Gemma, Lee, Shin W., Rikardsen, Lars K., Woods, Wendy S., George, Julia M., Rienstra, Chad M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3591419/
https://www.ncbi.nlm.nih.gov/pubmed/23505409
http://dx.doi.org/10.1371/journal.pone.0049750

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3591419/
https://www.ncbi.nlm.nih.gov/pubmed/23505409
http://dx.doi.org/10.1371/journal.pone.0049750

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