Molecular Basis for Jagged-1/Serrate Ligand Recognition by the Notch Receptor

We have mapped a Jagged/Serrate-binding site to specific residues within the 12th EGF domain of human and Drosophila Notch. Two critical residues, involved in a hydrophobic interaction, provide a ligand-binding platform and are adjacent to a Fringe-sensitive residue that modulates Notch activity. Ou...

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Detalles Bibliográficos
Autores principales: Whiteman, Pat, de Madrid, Beatriz Hernandez, Taylor, Paul, Li, Demin, Heslop, Rebecca, Viticheep, Nattnee, Tan, Joyce Zi, Shimizu, Hideyuki, Callaghan, Juliana, Masiero, Massimo, Li, Ji Liang, Banham, Alison H., Harris, Adrian L., Lea, Susan M., Redfield, Christina, Baron, Martin, Handford, Penny A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2013
Materias:
Signal Transduction
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3591638/
https://www.ncbi.nlm.nih.gov/pubmed/23339193
http://dx.doi.org/10.1074/jbc.M112.428854

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3591638/
https://www.ncbi.nlm.nih.gov/pubmed/23339193
http://dx.doi.org/10.1074/jbc.M112.428854

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