AP2 hemicomplexes contribute independently to synaptic vesicle endocytosis

The clathrin adaptor complex AP2 is thought to be an obligate heterotetramer. We identify null mutations in the α subunit of AP2 in the nematode Caenorhabditis elegans. α-adaptin mutants are viable and the remaining μ2/β hemicomplex retains some function. Conversely, in μ2 mutants, the alpha/sigma2...

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Detalles Bibliográficos
Autores principales: Gu, Mingyu, Liu, Qiang, Watanabe, Shigeki, Sun, Lin, Hollopeter, Gunther, Grant, Barth D, Jorgensen, Erik M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2013
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3591783/
https://www.ncbi.nlm.nih.gov/pubmed/23482940
http://dx.doi.org/10.7554/eLife.00190

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3591783/
https://www.ncbi.nlm.nih.gov/pubmed/23482940
http://dx.doi.org/10.7554/eLife.00190

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