The BET bromodomain inhibitor JQ1 activates HIV latency through antagonizing Brd4 inhibition of Tat-transactivation

Latent HIV reservoirs are the primary hurdle to eradication of infection. Identification of agents, pathways and molecular mechanisms that activate latent provirus may, in the presence of highly active antiretroviral therapy, permit clearance of infected cells by the immune system. Promoter-proximal...

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Detalles Bibliográficos
Autores principales: Li, Zichong, Guo, Jia, Wu, Yuntao, Zhou, Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3592394/
https://www.ncbi.nlm.nih.gov/pubmed/23087374
http://dx.doi.org/10.1093/nar/gks976

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3592394/
https://www.ncbi.nlm.nih.gov/pubmed/23087374
http://dx.doi.org/10.1093/nar/gks976

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