Single-molecule kinetics reveal microscopic mechanism by which High-Mobility Group B proteins alter DNA flexibility

Eukaryotic High-Mobility Group B (HMGB) proteins alter DNA elasticity while facilitating transcription, replication and DNA repair. We developed a new single-molecule method to probe non-specific DNA interactions for two HMGB homologs: the human HMGB2 box A domain and yeast Nhp6Ap, along with chimer...

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Detalles Bibliográficos
Autores principales: McCauley, Micah J., Rueter, Emily M., Rouzina, Ioulia, Maher, L. James, Williams, Mark C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Gene Regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3592474/
https://www.ncbi.nlm.nih.gov/pubmed/23143110
http://dx.doi.org/10.1093/nar/gks1031

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3592474/
https://www.ncbi.nlm.nih.gov/pubmed/23143110
http://dx.doi.org/10.1093/nar/gks1031

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