Identification of one of the apurinic/apyrimidinic lyase active sites of topoisomerase V by structural and functional studies

Topoisomerase V (Topo-V) is the only member of a novel topoisomerase subtype. Topo-V is unique because it is a bifunctional enzyme carrying both topoisomerase and DNA repair lyase activities within the same protein. Previous studies had shown that the topoisomerase domain spans the N-terminus of the...

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Detalles Bibliográficos
Autores principales: Rajan, Rakhi, Prasad, Rajendra, Taneja, Bhupesh, Wilson, Samuel H., Mondragón, Alfonso
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3592480/
https://www.ncbi.nlm.nih.gov/pubmed/23125368
http://dx.doi.org/10.1093/nar/gks1017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3592480/
https://www.ncbi.nlm.nih.gov/pubmed/23125368
http://dx.doi.org/10.1093/nar/gks1017

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