Mathematical Model of Metabolism and Electrophysiology of Amino Acid and Glucose Stimulated Insulin Secretion: In Vitro Validation Using a β-Cell Line

We integrated biological experimental data with mathematical modelling to gain insights into the role played by L-alanine in amino acid-stimulated insulin secretion (AASIS) and in D-glucose-stimulated insulin secretion (GSIS), details important to the understanding of complex β-cell metabolic coupli...

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Detalles Bibliográficos
Autores principales: Salvucci, Manuela, Neufeld, Zoltan, Newsholme, Philip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3592881/
https://www.ncbi.nlm.nih.gov/pubmed/23520444
http://dx.doi.org/10.1371/journal.pone.0052611

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3592881/
https://www.ncbi.nlm.nih.gov/pubmed/23520444
http://dx.doi.org/10.1371/journal.pone.0052611

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