Utilization of Quantitative In Vivo Pharmacology Approaches to Assess Combination Effects of Everolimus and Irinotecan in Mouse Xenograft Models of Colorectal Cancer

PURPOSE: The PI3K/AKT/mTOR pathway is frequently dysregulated in cancers and inhibition of mTOR has demonstrated the ability to modulate pro-survival pathways. As such, we sought to determine the ability of the mTOR inhibitor everolimus to potentiate the antitumor effects of irinotecan in colorectal...

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Detalles Bibliográficos
Autores principales: Bradshaw-Pierce, Erica L., Pitts, Todd M., Kulikowski, Gillian, Selby, Heather, Merz, Andrea L., Gustafson, Daniel L., Serkova, Natalie J., Eckhardt, S. Gail, Weekes, Colin D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3592886/
https://www.ncbi.nlm.nih.gov/pubmed/23520486
http://dx.doi.org/10.1371/journal.pone.0058089

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3592886/
https://www.ncbi.nlm.nih.gov/pubmed/23520486
http://dx.doi.org/10.1371/journal.pone.0058089

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