Glutathione S-transferase M1-null genotype as risk factor for SOS in oxaliplatin-treated patients with metastatic colorectal cancer

BACKGROUND: Oxaliplatin is used as a neo-adjuvant therapy in hepatic colorectal carcinoma metastasis. This treatment has significant side effects, as oxaliplatin is toxic to the sinusoidal endothelial cells and can induce sinusoidal obstruction syndrome (SOS), which is related to decreased overall s...

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Detalles Bibliográficos
Autores principales: Vreuls, C P H, Olde Damink, S W M, Koek, G H, Winstanley, A, Wisse, E, Cloots, R H E, van den Broek, M A J, Dejong, C H C, Bosman, F T, Driessen, A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Molecular Diagnostics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3593549/
https://www.ncbi.nlm.nih.gov/pubmed/23287989
http://dx.doi.org/10.1038/bjc.2012.590

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3593549/
https://www.ncbi.nlm.nih.gov/pubmed/23287989
http://dx.doi.org/10.1038/bjc.2012.590

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