Regulation of tamoxifen sensitivity by a PAK1–EBP1 signalling pathway in breast cancer

BACKGROUND: EBP1, an ErbB3-binding protein, sensitises breast cancer cells to tamoxifen in part by decreasing ErbB2 protein levels. The p21-regulated serine/threonine kinase PAK1, implicated in tamoxifen resistance, phosphorylates EBP1 in vitro and in vivo at T261. Phosphorylation of EBP1 at this si...

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Detalles Bibliográficos
Autores principales: Ghosh, A, Awasthi, S, Peterson, J R, Hamburger, A W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Translational Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3593557/
https://www.ncbi.nlm.nih.gov/pubmed/23361053
http://dx.doi.org/10.1038/bjc.2013.11

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3593557/
https://www.ncbi.nlm.nih.gov/pubmed/23361053
http://dx.doi.org/10.1038/bjc.2013.11

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