An inhibitor of the protein kinases TBK1/IKKε improves obesity-related metabolic dysfunctions

Emerging evidence suggests that inflammation provides a link between obesity and insulin resistance. The noncanonical IκB kinases IKKε and TANK-binding kinase 1 (TBK1) are induced in liver and fat after high fat diet by NF-κB activation, and in turn initiate a program of counter-inflammation that pr...

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Detalles Bibliográficos
Autores principales: Reilly, Shannon M., Chiang, Shian-Huey, Decker, Stuart J., Chang, Louise, Uhm, Maeran, Larsen, Martha J., Rubin, John R., Mowers, Jonathan, White, Nicole M., Hochberg, Irit, Downes, Michael, Yu, Ruth, Liddle, Christopher, Evans, Ronald M., Oh, Dayoung, Li, Pingping, Olefsky, Jerrold M., Saltiel, Alan R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3594079/
https://www.ncbi.nlm.nih.gov/pubmed/23396211
http://dx.doi.org/10.1038/nm.3082

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3594079/
https://www.ncbi.nlm.nih.gov/pubmed/23396211
http://dx.doi.org/10.1038/nm.3082

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