Cargando…

An inhibitor of the protein kinases TBK1/IKKε improves obesity-related metabolic dysfunctions

Emerging evidence suggests that inflammation provides a link between obesity and insulin resistance. The noncanonical IκB kinases IKKε and TANK-binding kinase 1 (TBK1) are induced in liver and fat after high fat diet by NF-κB activation, and in turn initiate a program of counter-inflammation that pr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Reilly, Shannon M., Chiang, Shian-Huey, Decker, Stuart J., Chang, Louise, Uhm, Maeran, Larsen, Martha J., Rubin, John R., Mowers, Jonathan, White, Nicole M., Hochberg, Irit, Downes, Michael, Yu, Ruth, Liddle, Christopher, Evans, Ronald M., Oh, Dayoung, Li, Pingping, Olefsky, Jerrold M., Saltiel, Alan R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3594079/ https://www.ncbi.nlm.nih.gov/pubmed/23396211 http://dx.doi.org/10.1038/nm.3082

Ejemplares similares

Inflammation produces catecholamine resistance in obesity via activation of PDE3B by the protein kinases IKKε and TBK1
por: Mowers, Jonathan, et al.
Publicado: (2013)

The TBK1/IKKε inhibitor amlexanox improves dyslipidemia and prevents atherosclerosis
por: Zhao, Peng, et al.
Publicado: (2022)

Roles for the IKK-Related Kinases TBK1 and IKKε in Cancer
por: Durand, Joel K., et al.
Publicado: (2018)

IKKε and TBK1 expression in gastric cancer
por: Eun Lee, Seung, et al.
Publicado: (2016)

Targeting HER2(+) breast cancer: the TBK1/IKKε axis
por: Jiang, Zhe, et al.
Publicado: (2014)

Inhibition of TBK1/IKKε Promotes Regeneration of Pancreatic β-cells
por: Xu, Jin, et al.
Publicado: (2018)

IKKε and TBK1 in diffuse large B‐cell lymphoma: A possible mechanism of action of an IKKε/TBK1 inhibitor to repress NF‐κB and IL‐10 signalling
por: Carr, Matthew, et al.
Publicado: (2020)

Development of a High-Throughput Assay for Identifying Inhibitors of TBK1 and IKKε
por: Hutti, Jessica E., et al.
Publicado: (2012)

MAVS activates TBK1 and IKKε through TRAFs in NEMO dependent and independent manner
por: Fang, Run, et al.
Publicado: (2017)

TBK1 and IKKε prevent TNF-induced cell death by RIPK1 phosphorylation
por: Lafont, Elodie, et al.
Publicado: (2018)

Publisher Correction: Inhibition of TBK1/IKKε Promotes Regeneration of Pancreatic β-cells
por: Xu, Jin, et al.
Publicado: (2019)

SPI-2/CrmA inhibits IFN-β induction by targeting TBK1/IKKε
por: Qin, Yue, et al.
Publicado: (2017)

TBK1 and IKKε act like an OFF switch to limit NLRP3 inflammasome pathway activation
por: Fischer, Fabian A., et al.
Publicado: (2021)

Functionally Distinct Effects of the C-Terminal Regions of IKKε and TBK1 on Type I IFN Production
por: Nakatsu, Yuichiro, et al.
Publicado: (2014)

Crosstalk between TBK1/IKKε and the type I interferon pathway contributes to tubulointerstitial inflammation and kidney tubular injury
por: Córdoba-David, Gina, et al.
Publicado: (2022)

Macrophages induce malignant traits in mammary epithelium via IKKε/TBK1 kinases and the serine biosynthesis pathway
por: Wilcz‐Villega, Ewa, et al.
Publicado: (2020)

Increased IKKϵ protein stability ensures efficient type I interferon responses in conditions of TBK1 deficiency
por: Wegner, Julia, et al.
Publicado: (2023)

Pharmacological inhibition of TBK1/IKKε blunts immunopathology in a murine model of SARS-CoV-2 infection
por: Ullah, Tomalika R., et al.
Publicado: (2023)

Epistatic effect of TLR3 and cGAS‐STING‐IKKε‐TBK1‐IFN signaling variants on colorectal cancer risk
por: Catalano, Calogerina, et al.
Publicado: (2019)

A novel TBK1/IKKϵ is involved in immune response and interacts with MyD88 and MAVS in the scallop Chlamys farreri
por: Liu, Wenjuan, et al.
Publicado: (2023)

The Specific IKKε/TBK1 Inhibitor Amlexanox Suppresses Human Melanoma by the Inhibition of Autophagy, NF-κB and MAP Kinase Pathways
por: Möller, Moritz, et al.
Publicado: (2020)

Acute TBK1/IKK-ε Inhibition Enhances the Generation of Disease-Associated Microglia-Like Phenotype Upon Cortical Stab-Wound Injury
por: Rehman, Rida, et al.
Publicado: (2021)

The Kinase MAP4K1 Inhibits Cytosolic RNA-Induced Antiviral Signaling by Promoting Proteasomal Degradation of TBK1/IKKε
por: He, Tian-Sheng, et al.
Publicado: (2021)

MCPIP1 negatively regulate cellular antiviral innate immune responses through DUB and disruption of TRAF3-TBK1-IKKε complex
por: Chen, Xiaojuan, et al.
Publicado: (2018)

Encephalomyocarditis virus 3C protease attenuates type I interferon production through disrupting the TANK–TBK1–IKKε–IRF3 complex
por: Huang, Li, et al.
Publicado: (2017)

Severe Acute Respiratory Syndrome Coronavirus M Protein Inhibits Type I Interferon Production by Impeding the Formation of TRAF3·TANK·TBK1/IKKϵ Complex
por: Siu, Kam-Leung, et al.
Publicado: (2009)

Interaction of Adipocyte Metabolic and Immune Functions Through TBK1
por: Zhao, Peng, et al.
Publicado: (2020)

A subcutaneous adipose tissue–liver signalling axis controls hepatic gluconeogenesis
por: Reilly, Shannon M., et al.
Publicado: (2015)

Importance of Validating Antibodies and Small Compound Inhibitors Using Genetic Knockout Studies—T Cell Receptor-Induced CYLD Phosphorylation by IKKε/TBK1 as a Case Study
por: Lork, Marie, et al.
Publicado: (2018)

A Rab10:RalA G protein cascade regulates insulin-stimulated glucose uptake in adipocytes
por: Karunanithi, Sheelarani, et al.
Publicado: (2014)

A co-crystal berberine-ibuprofen improves obesity by inhibiting the protein kinases TBK1 and IKKɛ
por: Wang, Man, et al.
Publicado: (2022)

Role of IKKε in the Metabolic Diseases: Physiology, Pathophysiology, and Pharmacology
por: Xiao, Qing-Ao, et al.
Publicado: (2022)

IKKε inhibits PKC to promote Fascin-dependent actin bundling
por: Otani, Tetsuhisa, et al.
Publicado: (2016)

Aphthous ulcer drug inhibits prostate tumor metastasis by targeting IKKɛ/TBK1/NF-κB signaling
por: Cheng, Chaping, et al.
Publicado: (2018)

Dual TBK1/IKKɛ inhibitor amlexanox attenuates the severity of hepatotoxin‐induced liver fibrosis and biliary fibrosis in mice
por: Zhou, Zixiong, et al.
Publicado: (2019)

Lentiviral delivery of combinatorial CAR/CRISPRi circuit into human primary T cells is enhanced by TBK1/IKKɛ complex inhibitor BX795
por: Li, Lingyu, et al.
Publicado: (2020)

The breast cancer oncogene IKKε coordinates mitochondrial function and serine metabolism
por: Xu, Ruoyan, et al.
Publicado: (2020)

The m6A demethylase ALKBH5 promotes tumor progression by inhibiting RIG-I expression and interferon alpha production through the IKKε/TBK1/IRF3 pathway in head and neck squamous cell carcinoma
por: Jin, Shufang, et al.
Publicado: (2022)

PSMB1 Negatively Regulates the Innate Antiviral Immunity by Facilitating Degradation of IKK-ε
por: Wu, Fangyi, et al.
Publicado: (2019)

IKKε isoform switching governs the immune response against EV71 infection
por: Chang, Ya-Ling, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_uel17i683emsoahd892ndlvonv