Cargando…

Steviol Reduces MDCK Cyst Formation and Growth by Inhibiting CFTR Channel Activity and Promoting Proteasome-Mediated CFTR Degradation

Cyst enlargement in polycystic kidney disease (PKD) involves cAMP-activated proliferation of cyst-lining epithelial cells and transepithelial fluid secretion into the cyst lumen via cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel. This study aimed to investigate an inhibi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yuajit, Chaowalit, Homvisasevongsa, Sureeporn, Chatsudthipong, Lisa, Soodvilai, Sunhapas, Muanprasat, Chatchai, Chatsudthipong, Varanuj
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3594167/ https://www.ncbi.nlm.nih.gov/pubmed/23536832 http://dx.doi.org/10.1371/journal.pone.0058871

Ejemplares similares

Antidiarrheal efficacy of a quinazolin CFTR inhibitor on human intestinal epithelial cell and in mouse model of cholera
por: Patanayindee, Jenvit, et al.
Publicado: (2012)

Inhibition of cAMP-Activated Intestinal Chloride Secretion by Diclofenac: Cellular Mechanism and Potential Application in Cholera
por: Pongkorpsakol, Pawin, et al.
Publicado: (2014)

Potential Application of Gambogic Acid for Retarding Renal Cyst Progression in Polycystic Kidney Disease
por: Khunpatee, Nutchanard, et al.
Publicado: (2022)

Farnesoid X Receptor Activation Stimulates Organic Cations Transport in Human Renal Proximal Tubular Cells
por: Wongwan, Teerasak, et al.
Publicado: (2020)

An Adult Mouse Model of Vibrio cholerae-induced Diarrhea for Studying Pathogenesis and Potential Therapy of Cholera
por: Sawasvirojwong, Sutthipong, et al.
Publicado: (2013)

Antidiabetic and Renoprotective Effects of Cladophora glomerata Kützing Extract in Experimental Type 2 Diabetic Rats: A Potential Nutraceutical Product for Diabetic Nephropathy
por: Srimaroeng, Chutima, et al.
Publicado: (2015)

Novel Potential Application of Chitosan Oligosaccharide for Attenuation of Renal Cyst Growth in the Treatment of Polycystic Kidney Disease
por: Pathomthongtaweechai, Nutthapoom, et al.
Publicado: (2020)

Impaired Insulin Signaling Affects Renal Organic Anion Transporter 3 (Oat3) Function in Streptozotocin-Induced Diabetic Rats
por: Lungkaphin, Anusorn, et al.
Publicado: (2014)

Spatial Turing-type Pattern Formation in a Model of Signal Transduction Involving Membrane-based Receptors Coupled by G Proteins
por: Rattanakul, Chontita, et al.
Publicado: (2007)

Discovery of Glycine Hydrazide Pore-occluding CFTR Inhibitors: Mechanism, Structure–Activity Analysis, and In Vivo Efficacy
por: Muanprasat, Chatchai, et al.
Publicado: (2004)

CFTR Gating I: Characterization of the ATP-dependent Gating of a Phosphorylation-independent CFTR Channel (ΔR-CFTR)
por: Bompadre, Silvia G., et al.
Publicado: (2005)

CFTR mutations altering CFTR fragmentation
por: Tosoni, Kendra, et al.
Publicado: (2012)

The additive effects of atorvastatin and insulin on renal function and renal organic anion transporter 3 function in diabetic rats
por: Thongnak, Laongdao, et al.
Publicado: (2017)

Discovering the chloride pathway in the CFTR channel
por: Farkas, Bianka, et al.
Publicado: (2019)

Regulation of CFTR Bicarbonate Channel Activity by WNK1: Implications for Pancreatitis and CFTR-Related Disorders
por: Kim, Yonjung, et al.
Publicado: (2019)

Reversible Silencing of CFTR Chloride Channels by Glutathionylation
por: Wang, Wei, et al.
Publicado: (2005)

Transmembrane helical interactions in the CFTR channel pore
por: Das, Jhuma, et al.
Publicado: (2017)

CFTR Protein: Not Just a Chloride Channel?
por: Hanssens, Laurence S., et al.
Publicado: (2021)

The molecular evolution of function in the CFTR chloride channel
por: Infield, Daniel T., et al.
Publicado: (2021)

Tweaking the catalytic efficiency of the CFTR ion channel
por: McCarty, Nael A.
Publicado: (2023)

Pharmacological Responses of the G542X-CFTR to CFTR Modulators
por: Fang, Xinxiu, et al.
Publicado: (2022)

Structural basis for the channel function of a degraded ABC transporter, CFTR (ABCC7)
por: Bai, Yonghong, et al.
Publicado: (2011)

Structural models of CFTR–AMPK and CFTR–PKA interactions: R-domain flexibility is a key factor in CFTR regulation
por: Siwiak, Marian, et al.
Publicado: (2011)

Cftr Channel Gating: Incremental Progress in Irreversible Steps
por: Csanády, László, et al.
Publicado: (1999)

CFTR, a rectifying, non-rectifying anion channel?
por: Quinton, P M, et al.
Publicado: (2000)

Modeling the Conformational Changes Underlying Channel Opening in CFTR
por: Rahman, Kazi S., et al.
Publicado: (2013)

Amelioration of Renal Inflammation, Endoplasmic Reticulum Stress and Apoptosis Underlies the Protective Effect of Low Dosage of Atorvastatin in Gentamicin-Induced Nephrotoxicity
por: Jaikumkao, Krit, et al.
Publicado: (2016)

Development of CFTR Structure
por: Patrick, Anna E., et al.
Publicado: (2012)

CFTR gets together
por: Sedwick, Caitlin
Publicado: (2019)

Is CFTR an exchanger?: Regulation of HCO(3)(−)Transport and extracellular pH by CFTR
por: Massey, Marija K., et al.
Publicado: (2020)

On the Mechanism of MgATP-dependent Gating of CFTR Cl(−) Channels
por: Vergani, Paola, et al.
Publicado: (2003)

Regulation of CFTR Cl- channel gating by ADP and ATP analogues
Publicado: (1995)

CFTR Functions as a Bicarbonate Channel in Pancreatic Duct Cells
por: Ishiguro, Hiroshi, et al.
Publicado: (2009)

A small molecule CFTR potentiator restores ATP‐dependent channel gating to the cystic fibrosis mutant G551D‐CFTR
por: Liu, Jia, et al.
Publicado: (2022)

PF‐06409577 inhibits renal cyst progression by concurrently inhibiting the mTOR pathway and CFTR channel activity
por: Su, Limin, et al.
Publicado: (2022)

Characterization of Nasal Potential Difference in cftr Knockout and F508del-CFTR Mice
por: Saussereau, Emilie Lyne, et al.
Publicado: (2013)

Extracellular phosphate enhances the function of F508del-CFTR rescued by CFTR correctors
por: Saint-Criq, Vinciane, et al.
Publicado: (2021)

Downregulation of CFTR Is Involved in the Formation of Hypertrophic Scars
por: Zhou, Yiwen, et al.
Publicado: (2020)

Hsp70 and DNAJA2 limit CFTR levels through degradation
por: Kim Chiaw, Patrick, et al.
Publicado: (2019)

CFTR activity and mitochondrial function()
por: Valdivieso, Angel Gabriel, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_mmuv88n7h16b2mcfp13q7qrll6