Cargando…

Rational Design of a Fibroblast Growth Factor 21-Based Clinical Candidate, LY2405319

Fibroblast growth factor 21 is a novel hormonal regulator with the potential to treat a broad variety of metabolic abnormalities, such as type 2 diabetes, obesity, hepatic steatosis, and cardiovascular disease. Human recombinant wild type FGF21 (FGF21) has been shown to ameliorate metabolic disorder...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kharitonenkov, Alexei, Beals, John M., Micanovic, Radmila, Strifler, Beth A., Rathnachalam, Radhakrishnan, Wroblewski, Victor J., Li, Shun, Koester, Anja, Ford, Amy M., Coskun, Tamer, Dunbar, James D., Cheng, Christine C., Frye, Christopher C., Bumol, Thomas F., Moller, David E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3594191/ https://www.ncbi.nlm.nih.gov/pubmed/23536797 http://dx.doi.org/10.1371/journal.pone.0058575

Ejemplares similares

LY2405319, an Engineered FGF21 Variant, Improves the Metabolic Status of Diabetic Monkeys
por: Adams, Andrew C., et al.
Publicado: (2013)

Fundamentals of FGF19 & FGF21 Action In Vitro and In Vivo
por: Adams, Andrew C., et al.
Publicado: (2012)

LY2405319, an analog of fibroblast growth factor 21 ameliorates α-smooth muscle actin production through inhibition of the succinate—G-protein couple receptor 91 (GPR91) pathway in mice
por: Le, Cong Thuc, et al.
Publicado: (2018)

FGF21 Requires βklotho to Act In Vivo
por: Adams, Andrew C., et al.
Publicado: (2012)

Distinct mobilization of leukocytes and hematopoietic stem cells by CXCR4 peptide antagonist LY2510924 and monoclonal antibody LY2624587
por: Peng, Sheng-Bin, et al.
Publicado: (2017)

FGF19 and FGF21: In NASH we trust
por: Talukdar, Saswata, et al.
Publicado: (2020)

Distinct lymphocyte antigens 6 (Ly6) family members Ly6D, Ly6E, Ly6K and Ly6H drive tumorigenesis and clinical outcome
por: Luo, Linlin, et al.
Publicado: (2016)

Novel PEGylated Basal Insulin LY2605541 Has a Preferential Hepatic Effect on Glucose Metabolism
por: Moore, Mary Courtney, et al.
Publicado: (2014)

Inventing new medicines: The FGF21 story()
por: Kharitonenkov, Alexei, et al.
Publicado: (2013)

FGF21 drives a shift in adipokine tone to restore metabolic health
por: Adams, Andrew Charles, et al.
Publicado: (2013)

Developmental and communicative interrelations of Ly123 and Ly1 cell sets
Publicado: (1980)

Another Kid on the Block: Long-acting FGF21 Analogue to Treat Dyslipidemia and Fatty Liver
por: Yang, Ranyao, et al.
Publicado: (2021)

Neces-SARI-ly?
por: Martin-Loeches, Ignacio, et al.
Publicado: (2016)

Running Mad-ly into mitosis
por: LeBrasseur, Nicole
Publicado: (2004)

Virulence profile: Hinh Ly
por: Ly, Hinh
Publicado: (2016)

Comparison of Mouse Ly5(a) and Ly5(b) Leucocyte Common Antigen Alleles
por: Zebedee, Suzanne L., et al.
Publicado: (1991)

Secretion of Ia antigens by a subpopulation of T cells which are Ly-1+, Ly-2-, and Ia-
Publicado: (1976)

Immunofluorescence laser micro-dissection of specific nephron segments in the mouse kidney allows targeted downstream proteomic analysis
por: Micanovic, Radmila, et al.
Publicado: (2015)

Expression of Ly 1, Ly 2, Thy 1, and TL differentiation antigens on mouse T-cell tumors
Publicado: (1978)

Occurrences and Functions of Ly6C(hi) and Ly6C(lo) Macrophages in Health and Disease
por: Li, Yuan-hui, et al.
Publicado: (2022)

Models of Ly$\alpha$ forest clouds
por: Charlton, J C
Publicado: (1995)

Role of Ly-6 in lymphocyte activation. II. Induction of T cell activation by monoclonal anti-Ly-6 antibodies
Publicado: (1986)

Crystal Structure of the FGFR4/LY2874455 Complex Reveals Insights into the Pan-FGFR Selectivity of LY2874455
por: Wu, Daichao, et al.
Publicado: (2016)

Influence of the Environment on Shaping the Absorption of Monomeric Infrared Fluorescent Proteins
por: Rathnachalam, Sivasudhan, et al.
Publicado: (2021)

Splenic Ly6G(high) mature and Ly6G(int) immature neutrophils contribute to eradication of S. pneumoniae
por: Deniset, Justin F., et al.
Publicado: (2017)

MSCs Contribute to the Conversion of Ly6C(high) Monocytes into Ly6C(low) Subsets under AMI
por: Lu, Wenbin, et al.
Publicado: (2020)

Bounded rationality alters the dynamics of paediatric immunization acceptance
por: Oraby, Tamer, et al.
Publicado: (2015)

LncRNA lncLy6C induced by microbiota metabolite butyrate promotes differentiation of Ly6C(high) to Ly6C(int/neg) macrophages through lncLy6C/C/EBPβ/Nr4A1 axis
por: Gao, Yunhuan, et al.
Publicado: (2020)

Ly phenotype of cytotoxic T cells for syngeneic tumor
Publicado: (1976)

Cell size control is sirtuin(ly) exciting
por: Wright, Jill, et al.
Publicado: (2013)

Independent differentiative pathways of Ly1 and Ly23 subclasses of T cells. Experimental production of mice deprived of selected T-cell subclasses
Publicado: (1976)

Mechanisms of Ly2 suppressor cell activity. Activation of an Ly1 I-J+ cell is required to transduce the suppressive signal
Publicado: (1984)

Functional subclasses of T lymphocytes bearing different Ly antigens. II. Cooperation between subclasses of Ly+ cells in the generation of killer activity
Publicado: (1975)

Varespladib (LY315920) and Methyl Varespladib (LY333013) Abrogate or Delay Lethality Induced by Presynaptically Acting Neurotoxic Snake Venoms
por: Gutiérrez, José María, et al.
Publicado: (2020)

LY3298176, a novel dual GIP and GLP-1 receptor agonist for the treatment of type 2 diabetes mellitus: From discovery to clinical proof of concept
por: Coskun, Tamer, et al.
Publicado: (2018)

Torsors, étale homotopy and applications to rational points
por: Skorobogatov, Alexei N
Publicado: (2013)

Conversion of Normal Ly-1-Positive B-Lineage Cells into Ly-1-Positive Macrophages in Long-Term Bone Marrow Cultures
por: Katoh, Shigeki, et al.
Publicado: (1990)

Ly6C(-) Monocytes Regulate Parasite-Induced Liver Inflammation by Inducing the Differentiation of Pathogenic Ly6C(+) Monocytes into Macrophages
por: Morias, Yannick, et al.
Publicado: (2015)

Ly6C(low) and Not Ly6C(high) Macrophages Accumulate First in the Heart in a Model of Murine Pressure-Overload
por: Weisheit, Christina, et al.
Publicado: (2014)

CCR2 Deficiency Impairs Ly6C(lo) and Ly6C(hi) Monocyte Responses in Orientia tsutsugamushi Infection
por: Petermann, Michael, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_q7uoeaf2gl3uf1m9vf2ob3m8ds