Acetylation Limits 53BP1 Association with Damaged Chromatin to Promote Homologous Recombination

The pathogenic sequelae of BRCA1 mutation in human and mouse cells are mitigated by concomitant deletion of 53BP1, which binds histone H4 dimethylated at Lys20 (H4K20me2) to promote nonhomologous end-joining, suggesting a balance between BRCA1 and 53BP1 regulates DNA double-strand break (DSB) repair...

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Detalles Bibliográficos
Autores principales: Tang, Jiangbo, Cho, Nam Woo, Cui, Gaofeng, Manion, Erica M., Shanbhag, Niraj M., Botuyan, Maria Victoria, Mer, Georges, Greenberg, Roger A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3594358/
https://www.ncbi.nlm.nih.gov/pubmed/23377543
http://dx.doi.org/10.1038/nsmb.2499

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3594358/
https://www.ncbi.nlm.nih.gov/pubmed/23377543
http://dx.doi.org/10.1038/nsmb.2499

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