Familial melanoma-associated mutations in p16 uncouple its tumor suppressor functions

Familial melanoma is associated with point mutations in the cyclin-dependent kinase (CDK) inhibitor p16(INK4A) (p16). We recently reported that p16 regulates intracellular oxidative stress in a cell cycle-independent manner. Here, we constructed 12 different familial melanoma-associated point mutant...

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Detalles Bibliográficos
Autores principales: Jenkins, Noah C., Jung, Jae, Liu, Tong, Wilde, Megan, Holmen, Sheri L., Grossman, Douglas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3594444/
https://www.ncbi.nlm.nih.gov/pubmed/23190892
http://dx.doi.org/10.1038/jid.2012.401

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3594444/
https://www.ncbi.nlm.nih.gov/pubmed/23190892
http://dx.doi.org/10.1038/jid.2012.401

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