Human IL2RA null mutation mediates immunodeficiency with lymphoproliferation and autoimmunity

Cell-surface CD25 expression is critical for maintaining immune function and homeostasis. As in few reported cases, CD25 deficiency manifests with severe autoimmune enteritis and viral infections. To dissect the underlying immunological mechanisms driving these symptoms, we analyzed the regulatory a...

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Detalles Bibliográficos
Autores principales: Goudy, Kevin, Aydin, Didem, Barzaghi, Federica, Gambineri, Eleonora, Vignoli, Marina, Mannurita, Sara Ciullini, Doglioni, Claudio, Ponzoni, Maurilio, Cicalese, Maria Pia, Assanelli, Andrea, Tommasini, Alberto, Brigida, Immacolata, Dellepiane, Rosa Maria, Martino, Silvana, Olek, Sven, Aiuti, Alessandro, Ciceri, Fabio, Roncarolo, Maria Grazia, Bacchetta, Rosa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academic Press 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3594590/
https://www.ncbi.nlm.nih.gov/pubmed/23416241
http://dx.doi.org/10.1016/j.clim.2013.01.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3594590/
https://www.ncbi.nlm.nih.gov/pubmed/23416241
http://dx.doi.org/10.1016/j.clim.2013.01.004

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