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On the selectivity of neuronal NOS inhibitors

BACKGROUND AND PURPOSE: Isoform-selective inhibitors of NOS enzymes are desirable as research tools and for potential therapeutic purposes. Vinyl-l-N-5-(1-imino-3-butenyl)-l-ornithine (l-VNIO) and N(ω)-propyl-l-arginine (NPA) purportedly have good selectivity for neuronal over endothelial NOS under...

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Detalles Bibliográficos
Autores principales: Pigott, B, Bartus, K, Garthwaite, J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3594681/
https://www.ncbi.nlm.nih.gov/pubmed/23072468
http://dx.doi.org/10.1111/bph.12016