Bax Exists in a Dynamic Equilibrium between the Cytosol and Mitochondria to Control Apoptotic Priming

The proapoptotic Bcl-2 protein Bax is predominantly found in the cytosol of nonapoptotic cells and is commonly thought to translocate to mitochondria following an apoptotic stimulus. The current model for Bax activation is that BH3 proteins bind to cytosolic Bax, initiating mitochondrial targeting a...

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Detalles Bibliográficos
Autores principales: Schellenberg, Barbara, Wang, Pengbo, Keeble, James A., Rodriguez-Enriquez, Ricardo, Walker, Scott, Owens, Thomas W., Foster, Fiona, Tanianis-Hughes, Jolanta, Brennan, Keith, Streuli, Charles H., Gilmore, Andrew P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3594749/
https://www.ncbi.nlm.nih.gov/pubmed/23375500
http://dx.doi.org/10.1016/j.molcel.2012.12.022

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3594749/
https://www.ncbi.nlm.nih.gov/pubmed/23375500
http://dx.doi.org/10.1016/j.molcel.2012.12.022

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