Discrete-State Stochastic Models of Calcium-Regulated Calcium Influx and Subspace Dynamics Are Not Well-Approximated by ODEs That Neglect Concentration Fluctuations

Cardiac myocyte calcium signaling is often modeled using deterministic ordinary differential equations (ODEs) and mass-action kinetics. However, spatially restricted “domains” associated with calcium influx are small enough (e.g., 10(−17) liters) that local signaling may involve 1–100 calcium ions....

Descripción completa

Detalles Bibliográficos
Autores principales: Weinberg, Seth H., Smith, Gregory D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3594940/
https://www.ncbi.nlm.nih.gov/pubmed/23509597
http://dx.doi.org/10.1155/2012/897371

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3594940/
https://www.ncbi.nlm.nih.gov/pubmed/23509597
http://dx.doi.org/10.1155/2012/897371

Ejemplares similares