α–SNAP inhibits AMPK signaling to reduce mitochondrial biogenesis and dephosphorylates Thr172 in AMPKα in vitro

The AMP-activated protein kinase (AMPK) regulates metabolism in normal and pathological conditions and responds to nutrients, hormones, anti-diabetic drugs and physical exercise. AMPK is activated by kinase LKB1 and inactivated by phosphatases whose identities remain uncertain. Here we show that AMP...

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Detalles Bibliográficos
Autores principales: Wang, Lifu, Brautigan, David L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3595137/
https://www.ncbi.nlm.nih.gov/pubmed/23463002
http://dx.doi.org/10.1038/ncomms2565

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3595137/
https://www.ncbi.nlm.nih.gov/pubmed/23463002
http://dx.doi.org/10.1038/ncomms2565

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