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Proteasome Activity Influences UV-Mediated Subnuclear Localization Changes of NPM
UV damage activates cellular stress signaling pathways, causes DNA helix distortions and inhibits transcription by RNA polymerases I and II. In particular, the nucleolus, which is the site of RNA polymerase I transcription and ribosome biogenesis, disintegrates following UV damage. The disintegratio...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3595268/ https://www.ncbi.nlm.nih.gov/pubmed/23554979 http://dx.doi.org/10.1371/journal.pone.0059096 |