ASPP1 and ASPP2 bind active RAS, potentiate RAS signalling and enhance p53 activity in cancer cells

RAS mutations occur frequently in human cancer and activated RAS signalling contributes to tumour development and progression. Apart from its oncogenic effects on cell growth, active RAS has tumour-suppressive functions via its ability to induce cellular senescence and apoptosis. RAS is known to ind...

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Detalles Bibliográficos
Autores principales: Wang, Y, Godin-Heymann, N, Dan Wang, X, Bergamaschi, D, Llanos, S, Lu, X
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3595493/
https://www.ncbi.nlm.nih.gov/pubmed/23392125
http://dx.doi.org/10.1038/cdd.2013.3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3595493/
https://www.ncbi.nlm.nih.gov/pubmed/23392125
http://dx.doi.org/10.1038/cdd.2013.3

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