Surface-Modified HK:siRNA Nanoplexes with Enhanced Pharmacokinetics and Tumor Growth Inhibition

[Image: see text] We characterized in this study the pharmacokinetics and antitumor efficacy of histidine-lysine (HK):siRNA nanoplexes modified with PEG and a cyclic RGD (cRGD) ligand targeting αvβ3 and αvβ5 integrins. With noninvasive imaging, systemically administered surface-modified HK:siRNA nan...

Descripción completa

Detalles Bibliográficos
Autores principales: Chou, Szu-Ting, Leng, Qixin, Scaria, Puthupparampil, Kahn, Jason D., Tricoli, Lucas J., Woodle, Martin, Mixson, A. James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2013
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3595641/
https://www.ncbi.nlm.nih.gov/pubmed/23360232
http://dx.doi.org/10.1021/bm3018356

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3595641/
https://www.ncbi.nlm.nih.gov/pubmed/23360232
http://dx.doi.org/10.1021/bm3018356

Ejemplares similares