Myosin phosphatase is inactivated by caspase-3 cleavage and phosphorylation of myosin phosphatase targeting subunit 1 during apoptosis

In nonapoptotic cells, the phosphorylation level of myosin II is constantly maintained by myosin kinases and myosin phosphatase. During apoptosis, caspase-3–activated Rho-associated protein kinase I triggers hyperphosphorylation of myosin II, leading to membrane blebbing. Although inhibition of myos...

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Detalles Bibliográficos
Autores principales: Iwasaki, Takahiro, Katayama, Takeshi, Kohama, Kazuhiro, Endo, Yaeta, Sawasaki, Tatsuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2013
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3596246/
https://www.ncbi.nlm.nih.gov/pubmed/23345589
http://dx.doi.org/10.1091/mbc.E11-08-0740

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3596246/
https://www.ncbi.nlm.nih.gov/pubmed/23345589
http://dx.doi.org/10.1091/mbc.E11-08-0740

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