Use of a Molecular Genetic Platform Technology to Produce Human Wnt Proteins Reveals Distinct Local and Distal Signaling Abilities

Functional and mechanistic studies of Wnt signaling have been severely hindered by the inaccessibility of bioactive proteins. To overcome this long-standing barrier, we engineered and characterized a panel of Chinese hamster ovary (CHO) cell lines with inducible transgenes encoding tagged and un-tag...

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Detalles Bibliográficos
Autores principales: Green, Jennifer L., Bauer, Matthieu, Yum, Kyu Won, Li, Yao-Cheng, Cox, Miranda L., Willert, Karl, Wahl, Geoffrey M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3596392/
https://www.ncbi.nlm.nih.gov/pubmed/23516471
http://dx.doi.org/10.1371/journal.pone.0058395

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3596392/
https://www.ncbi.nlm.nih.gov/pubmed/23516471
http://dx.doi.org/10.1371/journal.pone.0058395

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