Decoupling of DNA damage response signaling from DNA damages underlies temozolomide resistance in glioblastoma cells()

Glioblastoma multiforme (GBM) is the most aggressive primary brain tumor in adults. Current therapy includes surgery, radiation and chemotherapy with temozolomide (TMZ). Major determinants of clinical response to TMZ include methylation status of the O6-methylguanine-DNA methyltransferase (MGMT) pro...

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Detalles Bibliográficos
Autores principales: Cui, Bo, Johnson, Stewart P., Bullock, Nancy, Ali-Osman, Francis, Bigner, Darell D., Friedman, Henry S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Editorial Department of Journal of Biomedical Research 2010
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3596690/
https://www.ncbi.nlm.nih.gov/pubmed/23554659
http://dx.doi.org/10.1016/S1674-8301(10)60057-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3596690/
https://www.ncbi.nlm.nih.gov/pubmed/23554659
http://dx.doi.org/10.1016/S1674-8301(10)60057-7

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