Interleukin-6 Receptor Blockade Selectively Reduces IL-21 Production by CD4 T Cells and IgG4 Autoantibodies in Rheumatoid Arthritis

Interleukin-6 (IL-6) levels are known to be increased in patients with rheumatoid arthritis (RA). Tocilizumab, a monoclonal antibody to the IL-6 receptor (IL-6R), reduces disease activity in RA, although its mechanisms of action remain unclear. Since IL-6 regulates cytokine production by CD4 T cells...

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Detalles Bibliográficos
Autores principales: Carbone, Gustavo, Wilson, Augusta, Diehl, Sean A, Bunn, Janice, Cooper, Sheldon M., Rincon, Mercedes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2013
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3596713/
https://www.ncbi.nlm.nih.gov/pubmed/23493630
http://dx.doi.org/10.7150/ijbs.5996

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3596713/
https://www.ncbi.nlm.nih.gov/pubmed/23493630
http://dx.doi.org/10.7150/ijbs.5996

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