Cargando…

53BP1 facilitates long-range DNA end-joining during V(D)J recombination

V(D)J recombination and class switch recombination employ overlapping but distinct non-homologous end-joining (NHEJ) pathways to repair DNA double strand break (DSB) intermediates. 53BP1 is a DNA damage response protein that is rapidly recruited to sites of chromosomal DSBs, where it appears to func...

Descripción completa

Detalles Bibliográficos
Autores principales:	Difilippantonio, Simone, Gapud, Eric, Wong, Nancy, Huang, Ching-Yu, Mahowald, Grace, Chen, Hua Tang, Kruhlak, Michael J., Livak, Ferenc, Nussenzweig, Michel, Sleckman, Barry P., Nussenzweig, André
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2008
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3596817/ https://www.ncbi.nlm.nih.gov/pubmed/18931658 http://dx.doi.org/10.1038/nature07476

Ejemplares similares

53BP1 is required for class switch recombination
por: Ward, Irene M., et al.
Publicado: (2004)

53BP1 regulates DNA resection and the choice between classical and alternative end joining during class switch recombination
por: Bothmer, Anne, et al.
Publicado: (2010)

Ectopic expression of RNF168 and 53BP1 increases mutagenic but not physiological non-homologous end joining
por: Zong, Dali, et al.
Publicado: (2015)

Role of 53BP1 in end protection and DNA synthesis at DNA breaks
por: Paiano, Jacob, et al.
Publicado: (2021)

H2AX Is Required for Recombination Between Immunoglobulin Switch Regions but Not for Intra-Switch Region Recombination or Somatic Hypermutation
por: Reina-San-Martin, Bernardo, et al.
Publicado: (2003)

Alternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA ligase 4
por: Boboila, Cristian, et al.
Publicado: (2010)

Alternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA ligase 4
por: Boboila, Cristian, et al.
Publicado: (2013)

Distinct domains in Nbs1 regulate irradiation-induced checkpoints and apoptosis
por: Difilippantonio, Simone, et al.
Publicado: (2007)

53BP1 promotes microhomology-mediated end-joining in G1-phase cells
por: Xiong, Xiahui, et al.
Publicado: (2015)

Concurrent V(D)J recombination and DNA end instability increase interchromosomal trans-rearrangements in ATM-deficient thymocytes
por: Bowen, Steven, et al.
Publicado: (2013)

Out-of-Frame T Cell Receptor Beta Transcripts Are Eliminated by Multiple Pathways In Vivo
por: Mahowald, Grace K., et al.
Publicado: (2011)

TPX2 joins 53BP1 to maintain DNA repair and fork stability
por: Cantor, Sharon
Publicado: (2019)

BRCA1 Mutation-Specific Responses to 53BP1 Loss-Induced Homologous Recombination and PARP Inhibitor Resistance
por: Nacson, Joseph, et al.
Publicado: (2018)

SHLD1 is dispensable for 53BP1-dependent V(D)J recombination but critical for productive class switch recombination
por: Vincendeau, Estelle, et al.
Publicado: (2022)

LIN37-DREAM prevents DNA end resection and homologous recombination at DNA double-strand breaks in quiescent cells
por: Chen, Bo-Ruei, et al.
Publicado: (2021)

RIF1 Is Essential for 53BP1-Dependent Nonhomologous End Joining and Suppression of DNA Double-Strand Break Resection
por: Chapman, J. Ross, et al.
Publicado: (2013)

The ASCIZ-DYNLL1 axis promotes 53BP1-dependent non-homologous end joining and PARP inhibitor sensitivity
por: Becker, Jordan R., et al.
Publicado: (2018)

RIF1 Is Essential for 53BP1-Dependent Nonhomologous End Joining and Suppression of DNA Double-Strand Break Resection
por: Chapman, J. Ross, et al.
Publicado: (2021)

Loss of H3K36 Methyltransferase SETD2 Impairs V(D)J Recombination during Lymphoid Development
por: Chu, S. Haihua, et al.
Publicado: (2020)

ATM Is Required for Efficient Recombination between Immunoglobulin Switch Regions
por: Reina-San-Martin, Bernardo, et al.
Publicado: (2004)

Oncogenic KRAS drives radioresistance through upregulation of NRF2-53BP1-mediated non-homologous end-joining repair
por: Yang, Linlin, et al.
Publicado: (2021)

Opposing roles for 53BP1 during homologous recombination
por: Kakarougkas, Andreas, et al.
Publicado: (2013)

Heterochromatin is refractory to γ-H2AX modification in yeast and mammals
por: Kim, Jung-Ae, et al.
Publicado: (2007)

Measuring nonhomologous end-joining, homologous recombination and alternative end-joining simultaneously at an endogenous locus in any transfectable human cell
por: Hussain, Suleman S, et al.
Publicado: (2021)

The Role of Recombination Activating Gene (RAG) Reinduction in Thymocyte Development in Vivo
por: Yannoutsos, Nikos, et al.
Publicado: (2001)

The RNF8 and RNF168 Ubiquitin Ligases Regulate Pro- and Anti-Resection Activities at Broken DNA Ends During Non-Homologous End Joining
por: Chen, Bo-Ruei, et al.
Publicado: (2021)

A role for the p53 tumour suppressor in regulating the balance between homologous recombination and non-homologous end joining
por: Moureau, Sylvie, et al.
Publicado: (2016)

Non-homologous end joining in class switch recombination: the beginning of the end
por: Kotnis, Ashwin, et al.
Publicado: (2008)

Restrictions Limiting the Generation of DNA Double Strand Breaks during Chromosomal V(D)J Recombination
por: Tillman, Robert E., et al.
Publicado: (2002)

Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest
por: Sengupta, Sagar, et al.
Publicado: (2004)

Lack of MSH2 involvement differentiates V(D)J recombination from other non-homologous end joining events
por: Larijani, Mani, et al.
Publicado: (2005)

DNA-PK promotes DNA end resection at DNA double strand breaks in G(0) cells
por: Fowler, Faith C, et al.
Publicado: (2022)

Antigen Receptor Engagement Turns off the V(D)J Recombination Machinery in Human Tonsil B Cells
por: Meffre, Eric, et al.
Publicado: (1998)

The H2B deubiquitinase Usp22 promotes antibody class switch recombination by facilitating non-homologous end joining
por: Li, Conglei, et al.
Publicado: (2018)

V(D)J Recombination: Modulation of RAG1 and RAG2 Cleavage Activity on 12/23 Substrates by Whole Cell Extract and DNA-bending Proteins
por: Sawchuk, Dennis J., et al.
Publicado: (1997)

Impaired 53BP1/RIF1 DSB mediated end-protection stimulates CtIP-dependent end resection and switches the repair to PARP1-dependent end joining in G1
por: Bakr, Ali, et al.
Publicado: (2016)

Acetylation Limits 53BP1 Association with Damaged Chromatin to Promote Homologous Recombination
por: Tang, Jiangbo, et al.
Publicado: (2013)

Congenital bone marrow failure in DNA-PKcs mutant mice associated with deficiencies in DNA repair
por: Zhang, Shichuan, et al.
Publicado: (2011)

Evidence for Replicative Repair of DNA Double-Strand Breaks Leading to Oncogenic Translocation and Gene Amplification
por: Difilippantonio, Michael J., et al.
Publicado: (2002)

Involvement of Artemis in nonhomologous end-joining during immunoglobulin class switch recombination
por: Du, Likun, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_1n2sdb60sb2vr8bss2q099ret2