NODAL and SHH dose-dependent double inhibition promotes an HPE-like phenotype in chick embryos

Holoprosencephaly (HPE) is a common congenital defect that results from failed or incomplete forebrain cleavage. HPE is characterized by a wide clinical spectrum, with inter- and intrafamilial variability. This heterogeneity is not well understood and it has been suggested that HPE involves a combin...

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Detalles Bibliográficos
Autores principales: Mercier, Sandra, David, Véronique, Ratié, Leslie, Gicquel, Isabelle, Odent, Sylvie, Dupé, Valérie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Limited 2013
Materias:
Research Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3597036/
https://www.ncbi.nlm.nih.gov/pubmed/23264560
http://dx.doi.org/10.1242/dmm.010132

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3597036/
https://www.ncbi.nlm.nih.gov/pubmed/23264560
http://dx.doi.org/10.1242/dmm.010132

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