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NODAL and SHH dose-dependent double inhibition promotes an HPE-like phenotype in chick embryos
Holoprosencephaly (HPE) is a common congenital defect that results from failed or incomplete forebrain cleavage. HPE is characterized by a wide clinical spectrum, with inter- and intrafamilial variability. This heterogeneity is not well understood and it has been suggested that HPE involves a combin...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Company of Biologists Limited
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3597036/ https://www.ncbi.nlm.nih.gov/pubmed/23264560 http://dx.doi.org/10.1242/dmm.010132 |