Cargando…
Islet1 is a direct transcriptional target of the homeodomain transcription factor Shox2 and rescues the Shox2-mediated bradycardia
The heart’s rhythm is initiated and regulated by a group of specialized cells in the sinoatrial node (SAN), the primary pacemaker of the heart. Abnormalities in the development of the SAN can result in irregular heart rates (arrhythmias). Although several of the critical genes important for SAN form...
Autores principales: | Hoffmann, Sandra, Berger, Ina M., Glaser, Anne, Bacon, Claire, Li, Li, Gretz, Norbert, Steinbeisser, Herbert, Rottbauer, Wolfgang, Just, Steffen, Rappold, Gudrun |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer-Verlag
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3597335/ https://www.ncbi.nlm.nih.gov/pubmed/23455426 http://dx.doi.org/10.1007/s00395-013-0339-z |
Ejemplares similares
-
Coding and non-coding variants in the SHOX2 gene in patients with early-onset atrial fibrillation
por: Hoffmann, Sandra, et al.
Publicado: (2016) -
Shox2 mediates Tbx5 activity by regulating Bmp4 in the pacemaker region of the developing heart
por: Puskaric, Sandra, et al.
Publicado: (2010) -
The Homeobox Transcription Factor HOXA9 Is a Regulator of SHOX in U2OS Cells and Chicken Micromass Cultures
por: Durand, Claudia, et al.
Publicado: (2012) -
Identification of Novel SHOX Target Genes in the Developing Limb Using a Transgenic Mouse Model
por: Beiser, Katja U., et al.
Publicado: (2014) -
A Track Record on SHOX: From Basic Research to Complex Models and Therapy
por: Marchini, Antonio, et al.
Publicado: (2016)