Epstein - Barr Virus Transforming Protein LMP-1 Alters B Cells Gene Expression by Promoting Accumulation of the Oncoprotein ΔNp73α

Many studies have proved that oncogenic viruses develop redundant mechanisms to alter the functions of the tumor suppressor p53. Here we show that Epstein-Barr virus (EBV), via the oncoprotein LMP-1, induces the expression of ΔNp73α, a strong antagonist of p53. This phenomenon is mediated by the LMP...

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Detalles Bibliográficos
Autores principales: Accardi, Rosita, Fathallah, Ikbal, Gruffat, Henri, Mariggiò, Giuseppe, Le Calvez-Kelm, Florence, Voegele, Catherine, Bartosch, Birke, Hernandez-Vargas, Hector, McKay, James, Sylla, Bakary S., Manet, Evelyne, Tommasino, Massimo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3597522/
https://www.ncbi.nlm.nih.gov/pubmed/23516355
http://dx.doi.org/10.1371/journal.ppat.1003186

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3597522/
https://www.ncbi.nlm.nih.gov/pubmed/23516355
http://dx.doi.org/10.1371/journal.ppat.1003186

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