Detecting DNA Modifications from SMRT Sequencing Data by Modeling Sequence Context Dependence of Polymerase Kinetic

DNA modifications such as methylation and DNA damage can play critical regulatory roles in biological systems. Single molecule, real time (SMRT) sequencing technology generates DNA sequences as well as DNA polymerase kinetic information that can be used for the direct detection of DNA modifications....

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Detalles Bibliográficos
Autores principales: Feng, Zhixing, Fang, Gang, Korlach, Jonas, Clark, Tyson, Luong, Khai, Zhang, Xuegong, Wong, Wing, Schadt, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3597545/
https://www.ncbi.nlm.nih.gov/pubmed/23516341
http://dx.doi.org/10.1371/journal.pcbi.1002935

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3597545/
https://www.ncbi.nlm.nih.gov/pubmed/23516341
http://dx.doi.org/10.1371/journal.pcbi.1002935

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