rDNA-directed integration by an HIV-1 integrase—I-PpoI fusion protein

Integrating viral vectors are efficient gene transfer tools, but their integration patterns have been associated with genotoxicity and oncogenicity. The recent development of highly specific designer nucleases has enabled target DNA modification and site-specific gene insertion at desired genomic lo...

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Detalles Bibliográficos
Autores principales: Schenkwein, Diana, Turkki, Vesa, Ahlroth, Mervi K., Timonen, Oskari, Airenne, Kari J., Ylä-Herttuala, Seppo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Methods Online
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3597653/
https://www.ncbi.nlm.nih.gov/pubmed/23275537
http://dx.doi.org/10.1093/nar/gks1438

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3597653/
https://www.ncbi.nlm.nih.gov/pubmed/23275537
http://dx.doi.org/10.1093/nar/gks1438

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