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rDNA-directed integration by an HIV-1 integrase—I-PpoI fusion protein
Integrating viral vectors are efficient gene transfer tools, but their integration patterns have been associated with genotoxicity and oncogenicity. The recent development of highly specific designer nucleases has enabled target DNA modification and site-specific gene insertion at desired genomic lo...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3597653/ https://www.ncbi.nlm.nih.gov/pubmed/23275537 http://dx.doi.org/10.1093/nar/gks1438 |